big amounts of coffee are not great for the heart as well as blood vessels, however drinking just a couple of cups a day reduces the danger of cardiovascular disease. Epidemiologists have understood this for a few years. however exactly how moderate coffee intake protects the heart was not known. up until now.
The Camiseta CF Monterrey connection between coffee as well as cardiovascular illness is represented by a J-curve. The graph below is from a Finnish research study published Camiseta Bologna FC 1909 in 2004. [J Nutr. 2004 Sep;134(9):2381-6.] It shows the connection between coffee usage as well as the number of situations of heart attacks in middle-aged men.
The researchers monitored two thousand guy for five years.
As the graph shows, a coffee intake of six hundred millilitres each day has a protective effect. exactly how this works is explained in a Swiss research study published just recently in the American Journal of medical Nutrition. in that research study the researchers provided ten test subjects a cup of coffee early in the morning as well as then took blood samples. The Finns then subjected the ‘bad cholesterol’ LDL in the samples to copper ions. These oxidize LDL. Oxidized LDL is quite poor for the blood vessels.
The researchers observed that, after drinking coffee, the LDL Camiseta Atletico Madrid in the test subjects was secured against oxidation. At least, it took longer for the LDL to be oxidized.
Immediately after drinking the coffee nothing occurs – however the LDL in a sample taken half an hour after drinking coffee oxidizes much more slowly. as well as the LDL in a sample taken an hour after intake oxidizes even much more slowly.
When the researchers analyzed the LDL they saw why. After drinking the coffee, phenols in the coffee like ferulic acid as well as the associated chlorogenic acid embedded themselves in the LDL. These compounds avoid the LDL from being oxidized.
And it’s not only the phenols that are incorporated into LDL. “Incorporation into LDL was already shown for only a few other phenolic compounds”, the researchers write. They are referring to “quercetin as well as catechin, daidzein as well as genistein, rutin as well as quercetin, as well as tyrosol.” These substances are discovered in eco-friendly tea, soya as well as olive oil.
By the way, the research study was financed – you guessed it – by the food industry. In this situation by institutes with scientific sounding names funded by the sector, such as the Institute for scientific info on Coffee as well as the Physiological impacts of Coffee Committee.
Coffee drinking induces incorporation of phenolic acids into LDL as well as boosts the resistance of LDL to ex vivo oxidation in humans.
Abstract
BACKGROUND:
Epidemiologic as well as intervention studies suggest that both diet plan as a whole as well as single dietary elements are included in the danger of atherosclerosis. The resistance of LDL to oxidative adjustment is an ex vivo sign of risk, which is modulated by dietary components. Coffee includes phenolic compounds with antioxidant activity. These molecules are discovered in plasma after the usage of coffee, as well as it has been shown that, in vitro, they are able to decrease the susceptibility of LDL to oxidation.
OBJECTIVE:
The objective of this research study was to assess the impact of coffee usage on the redox condition of LDL as modulated by the possible incorporation of phenolic acids into LDL.
DESIGN:
Ten healthy volunteers, after an overnight fast, drank 200 mL filtered coffee. Blood was drawn before as well as 30 as well as 60 min after drinking. modifications in LDL redox condition were assessed by the determine of LDL resistance to oxidative adjustment as well as the concentration of LDL(-), a mildly modified, electronegative LDL subfraction. Chlorogenic as well as phenolic acids concentration in LDL were determined by electrochemical HPLC.
RESULTS:
The resistance of LDL to oxidative adjustment enhanced considerably after coffee drinking, however the LDL(-) concentration did not increase. The concentration into LDL of conjugated develops of caffeic, p-coumaric, as well as ferulic acids enhanced considerably after coffee drinking.
CONCLUSION:
Drinking 200 mL (1 cup) coffee induces an boost in the resistance of LDL to oxidative modification, most likely as a result of the incorporation of coffee’s phenolic acids into LDL.
PMID: 17823423 [PubMed – indexed for MEDLINE]
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